Dean and Sam are at a wits end. Everything seems to be falling apart, the world a few steps away from complete destruction. With everything on the line, the brothers finally begin to acknowledge that they need to work together, to stay together... to fight together. In the midst of impending and seemingly inevitable doom, the brothers come face to face with their destiny. Dean meets Elizabeth Fierce, a free spirited woman who insists on putting up the best fight possible; while Sam meets Cable Midnight, a sweet girl whose blood is causing quite the stir. Meanwhile, Lucifer's end game is to build up an army, not only to destroy Earth, but to war with Heaven. Once Michael is defeated, he plans on taking over Heaven as well.
To do this, he is recruiting psychics for his army and other special people who are willing to join him. This includes the cambions…strong beings with a strength that can put the best of demons to shame. He will use them in attempt to breach heaven’s gates and bring about a bloody war no one is expecting. Dean and Sam must stop him, as well as his Co-Pilot; a demon by the name of Maverick. But Lucifer is cunning and smart, distracting the Winchesters, angels and all hunters alike with the release of the alpha’s…original prototypes of all the monsters lurking in the dark.
With all this going on and the Horsemen rising one by one, the clock is ticking and the Winchesters don't have much time left to save the world. The boys are constantly coming face to face with death; sometimes literally so anyone close to them is never safe.
War - Rendered useless by the Winchesters Pestilence - Working to spread the Croatoan virus worldwide Famine - Busy reclaiming his strength by feeding on souls Death - Forced into aiding Lucifer, would rather help the Winchesters.